Caspase-9 swings both ways in the apoptosome
نویسندگان
چکیده
منابع مشابه
Regulation of the Apaf-1-caspase-9 apoptosome.
caspase-9 apoptosome Shawn B. Bratton1 and Guy S. Salvesen2 1Division of Pharmacology and Toxicology, College of Pharmacy, and Center for Molecular and Cellular Toxicology, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712-0125, USA 2Program in Apoptosis and Cell Death Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pi...
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Proteolytic processing of procaspase-9 is required for its activation, but processing in itself appears to be insufficient for its activity. We studied caspase activation in a cell-free system and found that incubation of cytosol from rat kidney proximal tubule cells with Cytochrome c (Cyt c) and dATP results in rapid autocatalytic processing of procaspase-9 from ~50 kD to ~38 kD size fragment....
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ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2017
ISSN: 2372-3556
DOI: 10.1080/23723556.2017.1281865